EXCITABILITY CONSTRAINTS ON VOLTAGE-GATED SODIUM CHANNELS.

We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels.The primary function of sodium channels is to allow the propagation of action potentials.Since Hodgkin and Huxley, mathematical models have suggested that sodium channel properties need to be tightly constrained for an action

Abstract Background Failure to be comprehensive can distort the results of a systematic review.Conversely, extensive searches may yield unmanageable number of citations of which only few may be relevant.Knowledge of usefulness of each source of information may help to tailor search strategies in systematic reviews.Methods We conducted a systematic